Mpaka

Build What Stays Hard

What's scarce when expert work is abundant

The digital products we want to build for the world's poorest countries are going to get easier and easier to make. And in many of the most important areas, the AI labs (OpenAI, Google, Anthropic and others) and the biggest funders are already putting serious money into making great tutors, safe clinical reasoning and AI that works in local languages.

I think that a year from now, a frontier model won't just be a high-quality tutor. I think it'll build a pedagogically sound tutoring product (with AI inside), add safety and learning guardrails, ship it, and run the data and experiment loop to improve it every week. If that's right, building a great product stops being the hard part.

But a good model and product aren't enough if they don't get used and don't change the outcome, as a trial at Penda Health's clinics in Kenya showed.

AI can make high-quality clinical decisions, but delivery is the bottleneck1Penda Health, Kenya: 1,000 urgent alerts from a randomised trial of GPT-4o's clinical advice
AI alert quality
92% safe and appropriate
Clinician response
20% fully followed AI alerts
57% partly followed
23% not followed
When clinicians didn't fully follow
13% justified
87% not justified

This is the question I came to next. If we really believe the models will keep getting better, and building an excellent digital product will become easy: what will limit impact then, and what should we do about it now?

I think this requires thinking about what a service needs beyond just intelligence and code:

What a service needs besides the model
  1. The modelExpert-level reasoningAbundant
  2. A product built for the contextIn the right language, on the right device, for the person using it
  3. DeliveryThe service redesigned so the AI can do the work, including how people work with it
  4. Permission and trustFrom government, regulators and the people using it
  5. Physical inputsDrugs, devices, trials, seeds

Which of these factors limits impact the most depends on the area. There are three major patterns across the seven highest-impact opportunities from Chapter I.

Area by area, what stays scarce falls into three patterns

1. Delivery

Clinical decisionsTeachingMental health

Running clinics, schools and counselling programmes where the AI does the expert work, showing they beat today’s service, and taking them into government. In mental health, it also means building the AI therapist, because the labs won’t.

2. Permission

TaxCourts

Only the state can audit a taxpayer or hear a case, so the work happens inside revenue authorities and courts. In tax, it also means building the product, because nobody is building it for the state.

3. Physical inputs

Drug discoveryAgricultural R&D

AI already helps with the design. What holds things back is trials, regulators, growing seasons and seed supply.

1. Delivery

In clinical decisions, teaching and mental health, the thing that remains scarce once we've got great AI doctors and teachers is delivery. That means figuring out how to actually have the AI deliver care and instruction.

Getting there will take two things. First, we need to prepare for a world where we get better results as the AI does more of the work. Then, we need to do the much harder job of actually redesigning the service to support that — including how we help humans (staff and users) to use it.

At Penda, high-quality AI advice wasn't enough. Unfortunately, this is not limited to one trial. Once the AI is better at a task than the person, adding the person tends to make the result worse.2 In medicine, that point seems to be arriving, as a recent JAMA piece suggests.

Doctors could improve the models' answers. Seven months later, they couldn't3OpenAI HealthBench: doctors were given model answers to health conversations and asked to write the best response

September 2024 models

GPT-4o and o1-preview

Doctors improved the answer 56%
Doctors made it worse 40%

April 2025 models

GPT-4.1 and o3

Doctors improved the answer 47%
Doctors made it worse 48%

The consensus in rich countries is that AI should support the doctor or teacher, never make clinical decisions or take on a large share of teaching. Because service quality is already pretty good, we don't lose too much upside from that decision.

I don't think it's obvious that we should apply the same heuristic in developing countries. We know that the quality of instruction and care is often poor, because teachers and clinicians are often working without much training or support. So this raises a question: if AI can deliver much better learning and care for nearly free, how far should we take it? This doesn't have an obvious answer, but I think we have a responsibility to have the conversation — and to raise our ambition for what AI can do.

As AI improves, having humans in the loop will likely worsen patient care.

Emanuel et al., JAMA (2026)4

But except for some areas like mental health or farmer advice, AI cannot actually deliver the service on its own. And we know that a great tool doesn't always get used (Penda had to do seven weeks of coaching before clinicians started responding to AI alerts).5 So the harder part is redesigning the service and all its human messiness so we actually get the benefit of AI.

This is a really hard problem, and mostly a service + organisational one, not a technical one:

It's very hard to figure these things out from outside, by selling a tool to someone else's clinic or school. But I think we can learn some lessons from the private sector's work on this question. Increasingly, we're seeing that getting value from AI is an organisational problem more than a technical one — it's far faster to rework a firm you own than to persuade someone else to rework theirs. So companies are converging on this understanding: the best way to iterate fast and deliver better results with AI is to own the full service including the outcome.

Some private companies now run the work themselves, so they can redesign it around AI6, 7, 8, 9

Akido

US clinics

Runs about 100 clinics. For Medicaid patients, a medical assistant runs the visit, the AI proposes the diagnosis and treatment, and a doctor approves afterwards.

4–5× as many patients per doctor

Moritz

Law

A law firm rather than a software company: the AI drafts, lawyers finish, and clients buy finished work at a fixed fee.

24 hours to draft a $290m services agreement

Thrive Holdings

Accounting and IT

Buys accounting and IT firms and rebuilds their work around AI, with OpenAI’s engineers working inside the companies. Its tax AI has processed more than 7,000 returns.

70+ firms owned

Some development organisations already work this way, and Penda is the clearest case. Because the trial ran in its own clinics, Penda can keep iterating on the system and testing again until it finds what works.

Penda redesigned the service in its own clinics one step at a time, and could test each step5, 1
  1. 2017Electronic records
  2. 2019–20Rule-based reminders: guideline adherence rose from 40% to over 90%
  3. 2024An AI tool clinicians could call on
  4. 2025The AI running in the background, with coaching
  5. 2025A randomised trial of 9,691 patients, in its own clinics

I'll call these lighthouses: organisations or sites where we can redesign the service around AI, improve outcomes, measure every test, and show others what works. Running your own sites isn't new. What would be new is doing the hard organisational and system-design work to rethink the service to deliver higher quality, greater reach, and/or dramatically lower cost with AI. This might look like existing operators choosing a few lighthouse sites, or new orgs launching to start (or even acquire) lighthouse clinics and schools, rather than focusing on tech.

AI capabilities have advanced much faster than their broad, real-world deployment, leaving a growing gap between what's possible and what people experience.

OpenAI, launching Horizon 1000 with the Gates Foundation10

OpenAI points to Penda as its example of closing that gap. In teaching, Rising Academies has started: it tested Rori, its AI maths tutor, in its own schools before taking it into government ones.

In mental health, I suspect a lighthouse also has to build the product, because the labs have chosen not to act as therapists.11 Counselling programmes like Friendship Bench, StrongMinds and Shamiri are natural places to build it.

Of course, most poor children go to public schools, and many poor families use public clinics. So a lighthouse only matters if what it proves becomes a public service, and that means working with government from the first day rather than arriving with results at the end. There are three routes to scale, and organisations are already on each. But I am still very uncertain about how we can iterate fast in lighthouses to build exceptionally cost-effective services, without falling into the trap of creating something which fails at national scale for political and implementation reasons.

Three routes from a lighthouse to scale, with organisations already on each12, 13, 14, 15, 16, 17, 18

A bigger network

Penda has grown to 20 centres, with nearly half a million visits a year.

A public payer

Kenya's Social Health Authority pays facilities per person, and has paid out KSh12.6bn to 7,282 facilities. A lighthouse clinic that qualifies grows on public money.

Government adopts the model

Rising Academies took Rori, its AI maths tutor, from 11 of its own schools, to a pilot that included 5 government schools, to a trial in 100 public schools. Muso's strategies, tested with Mali's government, became the basis of Mali's 2019 health reform.

2. Permission

In tax and courts, there's no lighthouse to run, because only the state can audit a taxpayer or hear a case. What's scarce is often permission to try. Although for tax, the product itself is likely also scarce: the models are getting much better at financial work, but this hasn't yet been pointed at the state.

In tax, the labs have signed the advisers, not the state19

Anthropic

  • Deloitte
  • PwC
  • Intuit
  • Anrok

OpenAI

  • Bain
  • H&R Block
  • Intuit

Revenue authorities

  • None found

Here, I think there is a really interesting opportunity to massively scale the impact of something like Tax Inspectors Without Borders (an OECD and UNDP scheme) with an AI-native tax inspection service.

An AI-native Tax Inspectors Without Borders, sketched20, 21
TIWB todayAn AI-native version
What it placesAudit experts, working on real cases alongside the country's auditors, at its requestAn AI that builds each case file, from the evidence to a draft assessment, alongside the same experts
Who decidesThe country's officersThe country's officers, signing every decision
What it's shownCorporate tax revenue 19–21% higher five to six years inNot yet built
Where its trust comes fromThe OECD and UNDP's name, and the political cover it bringsThe same, by running through TIWB

In courts, the product already exists: Adalat AI runs in thousands of Indian courtrooms, and Kerala has made it mandatory for recording evidence.22, 23 Here, permission is earned by easing one of the biggest pain points for judges, and the opportunity is to use that trust to expand across the court's work and into new judiciaries.

3. Physical inputs

In drug discovery and agricultural R&D, capital and effort are beginning to pour into generating new drug and seed candidates with AI. The timeline over which this bears fruit is uncertain, but impact will almost certainly be limited by the other parts of the process.

AI speeds up the first step. Most of the time and money go on the steps after it24, 25Green: the step AI does the thinking for, already being funded. Grey: physical steps it can't skip.

A new drug

  1. Choose the target and design the molecule
  2. Lab and animal tests
  3. Phase I trial
  4. Phase II trial
  5. Phase III trial
  6. Approval and supply

AI-found molecules pass Phase I 80–90% of the time, but Phase II only about 40%, no better than other drugs.

A new crop variety

  1. Choose the crosses from genetic data
  2. Trials at research stations, a season each
  3. Farmers' own trials
  4. Official release
  5. Multiplying the seed

Releasing a new variety can take more than a decade.

So the useful work there is building trial sites, speeding up regulators' reviews, and getting new seed multiplied and released — likely not another AI discovery organisation. Trials are the clearest gap: Africa hosted 1.1% of the clinical trials started worldwide in 2023.26

Area by area

As building the product gets easy, what limits impact differs by area
AreaGetting easierWhat will limit impactWhere the work is
Clinical decisionsClinical reasoning, and AI that advises health workersA service where the AI does the expert work, safelyLighthouse clinics, working with government from the start
TeachingTutoring, more than in any other areaA device, an hour in the timetable, an adult to run it, and someone to payLighthouse schools, working with government from the start
Mental healthLittle: the labs have chosen not to act as therapistsThe service itself, and getting people to start and finishLighthouse counselling programmes that also build the AI therapist
TaxThe capability, for firms and their advisersThe authority to use it on the state's sideInside the revenue authority, building the product too
CourtsA working product, in thousands of Indian courtroomsGetting each judiciary to adopt itTaking existing products into new judiciaries
Drug discoveryAI drug designTrials, regulators and moneyTrial sites and regulators
Agricultural R&DAI for breeding dataSeasons, seed and release rulesSeed systems and release rules

Next in the series: III. Forge →

Sources

  1. Agweyu et al. (2026), "Generative AI-enabled clinical decision support system in primary care: a pragmatic, cluster-randomized trial", Nature Medicine
  2. Vaccaro, Almaatouq and Malone (2024), "When combinations of humans and AI are useful: a systematic review and meta-analysis", Nature Human Behaviour
  3. Arora et al., OpenAI (2025), "HealthBench: evaluating large language models towards improved human health", arXiv 2505.08775. Built and graded by OpenAI
  4. Emanuel, Baker-Butler, Khosla and Khosla (2026), "Will autonomous AI exceed AI-aided physicians as the best medical care?", JAMA
  5. Korom et al. (2025), "AI-based clinical decision support for primary care", arXiv 2507.16947
  6. MIT Technology Review (22 September 2025), "The AI that could turn anyone into a doctor"
  7. Akido (30 July 2026), "Akido announces the first AI-native health system in the US"
  8. TechFundingNews (5 May 2026), "Moritz raises $9M"
  9. TechCrunch (12 August 2026), "OpenAI-backed Thrive Holdings raises $2B to bring AI to the enterprise"
  10. OpenAI (20 January 2026), "Horizon 1000"
  11. Anthropic (18 December 2025), "Protecting the well-being of users"
  12. Penda Health (September 2026), "Penda Health"
  13. OpenAI (July 2025), "AI clinical copilot at Penda Health"
  14. Willow Health Media (2026), "Kenya’s Ksh12.6 Billion Primary Healthcare Funds: A country analysis"
  15. Henkel et al. (2024), "Rori in 11 of Rising Academies' schools in Ghana", arXiv 2402.09809
  16. AEA RCT Registry (2025), "Rori's 17-school pilot", AEARCTR-0014476
  17. Rising Academies, "Testing Rori at scale: a new RCT in Ghana"
  18. Muso (26 February 2019), "Historic health reform announced in Mali"
  19. D. Mihaylov (June 2026), "The 2026 AI taxtech map"
  20. OECD and UNDP (2025), Tax Inspectors Without Borders Annual Report 2025
  21. Sabine Laudage Teles (2023), "Transfer Pricing Audit Trainings in the Global South: Are They Effective in Mobilizing Domestic Revenues?"
  22. Observer Research Foundation (5 August 2026), "Global AI Impact Commons: Stories from Adalat AI"
  23. Onmanorama (1 October 2025), "Kerala High Court on Adalat AI"
  24. Jayatunga et al. (2024), "How successful are AI-discovered drugs in clinical trials?", Drug Discovery Today
  25. CGIAR (28 May 2026), "Why crop breeding is entering an era of collaboration with AI"
  26. Jayasree K. Iyer, World Economic Forum (9 July 2025), "Improving access to innovative medicines in Africa starts with clinical trials"